The cover story of this month titled: “Top 10 Indian origin, BA/BE CROS to look upon in 2022” contributed by authored by Microbioz India, editorial. The key to making profits in the generic drug market is reaching the market as early as possible by getting proper regulatory approval. Generic medicines play an essential role in the pharmaceutical market because of their lower cost than branded drug molecules. Manufacturers of Generic Pharmaceuticals need not begin from scratch and carry out R&D, preclinical research, and early phase clinical trials. Instead, they need to show that their drug has a similar Bioavailability and Bioequivalence (BA/BE) as the branded drug. Regulatory bodies carry out a thorough inspection of the manufacturing plant and the clinical trial site and analyze the trial data to check if there has been any data fraud or manipulation.