The present research focused on the effect of positive thought induction e.g., package of relaxation, guided imagery, symptom management, etc. on the well-being, quality of life, coping strategies, clinical and immune parameters, disease progression in terms of symptoms management in people living with HIVAIDS in a controlled clinical research. Data were collected from 18 adult HIV patients having CD4 count above 250 and plasma viral load less than 5000, screened from a large group of HIV patients who had volunteered for the study. A pre-testpost-testfollow up design of research was adopted for the present study. Results indicated that post and follow-up tests for positive thought induction through hypnotherapy had yielded significant positive changes in several dimensions of coping strategies e.g., active coping, alcoholdrug abuse, denial, planning, reinterpretation and growth. Similarly, it led to significant increase in different Immunological parameters e.g., of CD4 count, absolute CD4 count, absolute CD8 count, proportion of CD4 to CD8 count, and absolute CD3 count. These results are discussed in the light of recent theoretical developments in the area of clinical hypnotherapy. Clinical hypnotherapy in people living with HIVAIDS: A study of disease progression and coping strategies